AIM CellSparc 360®
The cardiovascular system consists of the heart and
blood vessels. Heart disease is the biggest killer in North America.
It includes structural or functional abnormalities
of the heart, or of the blood vessels supplying the heart, that impair
its normal functioning. Cholesterol contributes to buildup of plaque in
the coronary arteries that restricts blood flow to the heart, causing
chest pain, and possibly leading to heart attack and death.
In addition to eating a nutritious diet and getting
adequate exercise, supplementation with coenzyme Q10 (CoQ10),
tocotrienols, and fish oil can help maintain heart health.
AIM CellSparc 360® combines CoQ10, tocotrienols, and
fish oil to provide you with the ultimate heart health product. These
three ingredients work together to ensure adequate energy production at
the cellular level and to maintain a healthy lipid profile. They truly
provide a synergistic effect for heart health. Coenzyme
Q10
All living cells require adenosine triphosphate (ATP) to
function. ATP represents a major source of stored energy in the body and
is responsible for many metabolic processes. CoQ10 is key in the
production of ATP. CoQ10, or ubiquinone, is found
throughout the body in cell membranes, especially mitochondrial
membranes, the areas of cells where food is converted to energy.
According to a 1990 article in the American Journal of Cardiology,
“Coenzyme Q10 is necessary for the mitochondria to perform their
functions and is essential for human life.” CoQ10 is most abundant in
the heart, lungs, liver, kidneys, and spleen. Without
adequate levels of CoQ10, the body cannot produce adequate levels of
ATP. When you consider that the average person uses 60 percent of his or
her daily energy alone on base metabolism, you can see how important
CoQ10 is in ensuring that the body is able to create enough energy for
both its millions of everyday tasks and its special energy needs.
In the mid-1960s, Japanese professor Yamamura was the first clinician to
use coenzyme Q7 (a compound related to CoQ10) in the treatment of
congestive heart failure. Since then, numerous clinical trials have
demonstrated the efficacy of CoQ10 in promoting cardiac health
(Langsjoen et al. 1994, Greenberg and Frishman 1990). A
recent literature review looked at clinical trials, articles, reviews,
and letters published over the past 25 years in regard to the role of
CoQ10 in heart failure (Tran et al. 2001). The review indicates that
CoQ10 helps in how efficiently the heart pumps (ejection fraction), how
well the heart functions when it is made to work harder (exercise
tolerance), how much blood is pumped by the heart (stroke volume), and
how much blood the heart can pump in one minute (cardiac output.)
The abstract of the review indicates that “the use of CoQ10 as adjuvant
therapy in patients with chronic heart failure may be supported.”
Japanese researchers have also found that CoQ10 supplementation prior to
and immediately following open-heart surgery is highly beneficial in
preventing injuries related to reperfusion, restoring blood flow to
organs and tissues. Studies also indicate that CoQ10
supplementation may decrease the amount of medication used by heart
disease patients, improve health as measured by the New York Heart
Association functional scale, improve overall quality of life for heart
patients, and act to maintain healthy blood pressure levels.
In addition to cardiac benefits, CoQ10 has been positively researched
with regard to periodontal disease, athletic performance (stressful
exercise reduces blood levels of CoQ10), muscular dystrophy, immunity
and infections, and HIV. CoQ10 also seems to be a helpful
secondary therapy in some cancers. This is supported by research in
regard to colon and prostatic cancers and anecdotal reports in relation
to pancreatic and lung cancer. Tocotrienols
Tocotrienols are a form of vitamin E. The term “vitamin
E” actually describes a group of eight fat-soluble compounds—alpha-,
beta-, delta-, and gamma-tocopherol and alpha-, beta-, delta-, and
gammatocotrienol. Usually, vitamin E is loosely used to
refer to alpha-tocopherol. Tocotrienols are found in
cereal seeds and rice bran, and in palm and barley oils. Research
indicates that tocotrienols have antitumor and antioxidant properties
and may reduce cholesterol.
In one study, 90 people with high cholesterol levels followed the
American Heart Association (AHA) Step-1 diet and took 100 mg of
tocotrienols for a 35-day period. This program reduced
their total cholesterol levels 20 percent and their LDL cholesterol
levels—the “bad cholesterol”—25 percent compared to their cholesterol
levels at the beginning of the study (Qureshi et al. 2002).
Another study (Serbinova and Packer 1994) shows that tocotrienols have
40 to 60 times more antioxidant ability than alpha-tocopherol—vitamin E.
Fish oil
Diets high in saturated fats have been linked to high
blood cholesterol levels. Epidemiological studies have shown that in
populations where large amounts of fish are consumed, there is little
evidence of heart disease. The U.S. Physicians’ Health
Study found that men who consumed fish one time per week cut their risk
of sudden cardiac death by 52 percent compared with men who ate fish
less than one time per month (Albert, et al. 1998). A
recent meta-analysis indicated that the use of dietary and supplemental
omega-3 polyunsaturated fatty acids reduces overall mortality, mortality
due to myocardial infarction, and sudden death in patients with coronary
heart disease (Bucher et al. 2002). Fish oil has also
been found to help reduce triglyceride—a type of fat—levels. High
triglyceride levels are a factor in heart disease. Fish
oils are rich in eicosapentaenoic acid (EPA) and docosahexaenoic acid
(DHA), which are believed to decrease the risk of thrombosis (blood
clot) and lower blood pressure. In addition to its health
benefits, fish oil is used in AIM CellSparc 360® as a dissolvent for the
CoQ10 and tocotrienols. Dr. Karl Folkers, the doctor responsible for
much of the research on CoQ10, recommended that it be dissolved in oil.
Because CoQ10 is fat-soluble, it requires fat to be absorbed by the
digestive tract. How to use AIM CellSparc 360®
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Suggested use: 1 to 2 softgel capsules per day.
Although the inclusion of the fish oil diluent helps improve
absorption of the CoQ10, it is still recommended that you take the
capsules with meals. Some people feel immediate benefits; others
notice results after 6 to 8 weeks.
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Close tightly after opening and store in a cool,
dry, dark place (70-75 °F; 20.1-23.8 °C).
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Do not refrigerate.
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If pregnant or nursing, consult a health
practitioner.
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Diabetics should consult a health practitioner.
Coenzyme Q10 and human nutrition
CoQ10 is found in the foods we eat, but not often in
large amounts. The best sources of CoQ10 are animal organs, some types
of fish, and vegetable oils such as soybean, rapeseed, and sesame. It is
found in lesser quantities in rice bran and wheat germ and in soy and
other beans. It is also found in vegetables, in particular spinach and
broccoli. CoQ10 is easily destroyed in the cooking process, and much of
the CoQ10 is removed in refined grains. The body can also
manufacture CoQ10 from other members of the coenzyme Q (CoQ) family.
CoQ10 is but one of ten, and possibly more, members of the CoQ family. A
meal consisting of shellfish, vegetables, and mushrooms provides CoQ9
and CoQ7. To change these CoQs into CoQ10, the liver breaks them down
and reassembles them. The creation of CoQ10 by the body
is a complex process. At least three different classes of starting
molecules are required, at least 15 different reactions are necessary
(each begun by an enzyme), and many cofactor substances are involved.
Because all the component parts must be available in sufficient
quantities at the same time, CoQ10 is difficult for the body to produce.
Some of the essential cofactors are not created by the body. A
deficiency in any of these—vitamins B3, B5, B6, B12, C, and folate—would
make it difficult for the liver to produce enough CoQ10. Unfortunately,
the older you get, the less ability you have to produce CoQ10 from other
members of the CoQ family. Our lives and environments
also affect CoQ10 levels, in that stressful lives and polluted
environments can deplete CoQ10 from body tissue.
According to Dr. Folkers, these factors—nutrient deficiencies, age,
stress, and pollution—could lead to a deficiency of CoQ10. By some
estimates, as many as 75 percent of people over age 50 in the United
States could be deficient in CoQ10. Q & A
Why should I take AIM CellSparc 360®?
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Studies have found that as we age, our bodies cannot
produce CoQ10 as efficiently and its supply diminishes. It is
important to keep adequate levels of CoQ10 in our bodies. However,
finding healthy food sources of CoQ10 can be difficult. The best
sources of CoQ10 are animal muscle tissues, but many people prefer
not to eat this type of food. The CoQ10 in AIM CellSparc 360® is
produced from plant sources. Using it provides a way of maintaining
the body’s level of CoQ10 without compromising other dietary
considerations.
Can I take more than the suggested amount?
Why must I store AIM CellSparc 360® in a cool, dry,
dark place?
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Because the CoQ10 used in AIM CellSparc 360® is so
pure, it has a relatively low melting temperature. This will not
hurt the efficacy of the product. However, heat, humidity, and
sunlight could cause the softgels to stick together.
Softgel capsules and absorption
A softgel delivery system can increase the absorption of
the product. A double-blind, controlled study shows that an oil-diluent
softgel CoQ10 formulation has an absorption rate almost three times
higher than that of a dry capsule CoQ10 formulation. An
oil-diluent softgel formulation resulted in a CoQ10 blood level of 265
percent over the base level, while a dry capsule form of CoQ10 resulted
in a blood level of 180 percent over the base level.
The dry capsule CoQ10 was absorbed at 3.4 micrograms per minute, while
the oil-diluent softgel CoQ10 was absorbed at 9.3 micrograms per
minute—a 273 percent difference. This greater bioavailability appears to
affect energy. Results show that 83 percent of those who used the oil-diluent
softgel form experienced more energy, compared to 30 percent of those
who used the dry capsule form.
 References
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Albert, C.M., et al. “Fish Consumption and Risk of
Sudden Cardiac Death.” Journal of the American Medical Association
279 (1998): 23-28.
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Bucher, H.C., et al. “N-3 [Omega-3] Polyunsaturated
Fatty Acids in Coronary Heart Disease: A Meta-Analysis of Randomized
Controlled Trials.” American Journal of Medicine 112, no. 4 (2002):
298-304.
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Greenberg, A., and W. Frishman. “Coenzyme Q10: A New
Drug for Cardiovascular Health.” Journal of Clinical Pharmacology
30, no. 7 (July 1990): 596-608.
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Langsjoen, P., P. Langsjoen, R. Willis, and K.
Folkers. “Treatment of Essential Hypertension with Coenzyme Q10.”
Molecular Aspects of Medicine 15 Suppl (1994): S265-272.
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Qureshi, A.A., et al. “Dose-Dependent Suppression of
Serum Cholesterol by Tocotrienol-Rich Fraction (TRF(25)) of Rice
Bran in Hypercholesterolemic Humans.” Atherosclerosis 161, no. 1
(2002): 199-207.
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Serbinova, E.A., and L. Packer. “Antioxidant
Properties of Alpha-Tocopherol and Alpha-Tocotrienol.” Methods
Enzymol. 234 (1994): 354-366.
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Tran, M.T., et al. “Role of Coenzyme Q10 in Chronic
Heart Failure, Angina, and Hypertension.” Pharmacotherapy 21, no. 7
(2001): 797-806.
coenzyme Q10, of tocotrienols AIM CellSparc 360® in
Canada ! main
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